Mineralocorticoid receptor overexpression facilitates differentiation and 1 promotes survival of embryonic stem cell - derived neurons
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چکیده
4 Service d’Endocrinologie et Maladies de la Reproduction, Assistance Publique-Hôpitaux de Paris, 14 Hôpital de Bicêtre, Le Kremlin-Bicêtre, F-94275, France. 15 16 Corresponding author’s address: Marc Lombès, INSERM U693, Faculté de Médecine Paris-Sud 11, 17 63, rue Gabriel Péri, 94276 Le Kremlin-Bicêtre Cedex France. E-mail: [email protected]. Tel : 18 +33 1 49 59 67 09. Fax : + 33 1 49 59 67 32 19
منابع مشابه
Mineralocorticoid receptor overexpression facilitates differentiation and promotes survival of embryonic stem cell-derived neurons.
Mineralocorticoid receptor (MR), highly expressed in the hippocampus, binds corticosteroid hormones and coordinately participates, with the glucocorticoid receptor, to the control of stress responses, memorization, and behavior. To investigate the impact of MR in neuronal survival, we generated murine embryonic stem (ES) cells that overexpress human MR (hMR) (P1-hMR) and are induced to differen...
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متن کاملDifferentiation of human embryonic stem cells into neurons
Human embryonic stem (ES) cells are undifferentiated pluripotent cells derived from the inner cell mass of blastocyst stage embryos. These unique cell lines have the potential to form virtually any cell type in the body and can be propagated in vitro indefinitely in an undifferentiated state. These cells are capable of forming embryoid bodies (EB) that contain cells from all three embryonic lin...
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تاریخ انتشار 2012